N-Acetylcysteine and N-Nitroarginine Methyl Ester Attenuate Carboplatin-Induced Ototoxicity in Dissociated Spiral Ganglion Neuron Cultures

N-Acetylcysteine and N-Nitroarginine Methyl Ester Attenuate Carboplatin-Induced Ototoxicity in Dissociated Spiral Ganglion Neuron Cultures

ObjectivesCarboplatin, a platinum-containing anti-cancer drug used to treat a variety of cancers, induces ototoxicity. Since, reactive oxygen species (ROS) and nitric oxide (NO) seem to be responsible for this toxicity, the antioxidant, N-acetyl-L-cysteine (L-NAC), and NO synthetase inhibitor, N-nit...

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Bibliographic Details
Main Authors: Il Joon Moon, Ki Ryung Kim, Ho-Suk Chu, Se Hyung Kim, Won-Ho Chung, Yang-Sun Cho, Sung Hwa Hong
Format: Article
Language:English
Published: Korean Society of Otorhinolaryngology-Head and Neck Surgery 2011-03-01
Series:Clinical and Experimental Otorhinolaryngology
Subjects:
Ototoxicity
Carboplatin
Nitric oxide
Spiral ganglion neuron
Inner hair cell
Outer hair cell
Mouse
Online Access:http://www.e-ceo.org/upload/pdf/ceo-4-11.pdf

Internet

http://www.e-ceo.org/upload/pdf/ceo-4-11.pdf

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