DNA Damage Tolerance Mechanisms Revealed from the Analysis of <i>Immunoglobulin V</i> Gene Diversification in Avian DT40 Cells

DNA replication is an essential biochemical reaction in dividing cells that frequently stalls at damaged sites. Homologous/homeologous recombination (HR)-mediated template switch and translesion DNA synthesis (TLS)-mediated bypass processes release arrested DNA replication forks. These mechanisms ar...

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Bibliographic Details
Main Authors: Takuya Abe, Dana Branzei, Kouji Hirota
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/9/12/614