Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex.

The mechanistic target of rapamycin (mTOR) signaling pathway is highly conserved from yeast to humans. It senses various environmental cues to regulate cellular growth and homeostasis. Deregulation of the pathway has been implicated in many pathological conditions including cancer. Phosphorylation c...

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Bibliographic Details
Main Authors: Hirokazu Okada, Ralf B Schittenhelm, Anna Straessle, Ernst Hafen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368434?pdf=render