LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

ObjectivesThe concept of trained innate immunity describes a long-term proinflammatory memory in innate immune cells. Trained innate immunity is regulated through reprogramming of cellular metabolic pathways including cholesterol and fatty acid synthesis. Here, we have analyzed the role of Liver X R...

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Bibliographic Details
Main Authors: Yahya Sohrabi, Glenn V. H. Sonntag, Laura C. Braun, Sina M. M. Lagache, Marie Liebmann, Luisa Klotz, Rinesh Godfrey, Florian Kahles, Johannes Waltenberger, Hannes M. Findeisen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
trained innate immunity
monocytes
LXR
acetyl-CoA
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00353/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00353/full

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