Mfn2 inhibits proliferation and cell-cycle in Hela cells via Ras-NF-κB signal pathway

Abstract Background Mitofusin 2 (Mfn2) is outer membrane protein, as the inhibitor of Ras protein. This study aimed to investigate the effect of Mfn2 on cell proliferation, and cell-cycle in Hela cervical carcinoma cell lines. Methods After treated with Adv-mfn2 or Adv-control for 48 h and 60 h, the...

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Bibliographic Details
Main Authors: Xiaowen Liu, Jun Sun, Ping Yuan, Kangquan Shou, Yuanhong Zhou, Wenqi Gao, Jin She, Jun Hu, Jun Yang, Jian Yang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cancer Cell International
Subjects:
Ras
Online Access:http://link.springer.com/article/10.1186/s12935-019-0916-9