Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs

Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs

Abstract Background Our understanding of eukaryotic gene regulation is limited by the complexity of protein–DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. We recently introduced CUT&RUN, an antibody-targeted nuclease cleav...

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Bibliographic Details
Main Authors: Derek H. Janssens, Steven J. Wu, Jay F. Sarthy, Michael P. Meers, Carrie H. Myers, James M. Olson, Kami Ahmad, Steven Henikoff
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Epigenetics & Chromatin
Subjects:
CUT&RUN
Histone modifications
Transcription factors
Chromatin regulators
Online Access:http://link.springer.com/article/10.1186/s13072-018-0243-8

Internet

http://link.springer.com/article/10.1186/s13072-018-0243-8

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