Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses

Multipotent human mesenchymal stromal cells (hMSCs) harbor immunomodulatory properties that are therapeutically relevant. One of the most clinically important populations of leukocytes is the interleukin-17A (IL-17A)-secreting T (Th17) lymphocytes. However, mechanisms of hMSC and Th17 cell interacti...

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Bibliographic Details
Main Authors: Wei-Bei Wang, Men-Luh Yen, Ko-Jiunn Liu, Pei-Ju Hsu, Ming-Hong Lin, Pei-Min Chen, Putty-Reddy Sudhir, Chein-Hung Chen, Chung-Hsuan Chen, Huei-Kang Sytwu, B. Linju Yen
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115002192

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http://www.sciencedirect.com/science/article/pii/S2213671115002192

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