Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway

The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the...

Full description

Bibliographic Details
Main Authors: Irina Alecu, Alaa Othman, Anke Penno, Essa M. Saied, Christoph Arenz, Arnold von Eckardstein, Thorsten Hornemann
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752031436X