High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins

High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins

Efforts to elucidate the role of lipoprotein [a] (Lp[a]) in atherogenesis have been hampered by the lack of an animal model with high plasma Lp[a] levels. We produced two lines of transgenic mice expressing apolipoprotein [a] (apo[a]) in the liver and crossed them with mice expressing human apolipop...

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Bibliographic Details
Main Authors: Matthias Schneider, Joseph L. Witztum, Stephen G. Young, Erwin H. Ludwig, Elizabeth R. Miller, Sotirios Tsimikas, Linda K. Curtiss, Santica M. Marcovina, John M. Taylor, Richard M. Lawn, Thomas L. Innerarity, Robert E. Pitas
Format: Article
Language:English
Published: Elsevier 2005-04-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
oxidized low density lipoprotein
apolipoprotein [a]
cardiovascular
apolipoprotein B-100
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520340128

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http://www.sciencedirect.com/science/article/pii/S0022227520340128

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