Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.

Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.

New effective compounds for tuberculosis treatment are needed. This study evaluated the effects of a series of quinoxaline-derived chalcones against laboratorial strains and clinical isolates of M. tuberculosis. Six molecules, namely N5, N9, N10, N15, N16, and N23 inhibited the growth of the M. tube...

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Bibliographic Details
Main Authors: Thaís C Muradás, Bruno L Abbadi, Anne D Villela, Fernanda S Macchi, Pedro F Bergo, Talita F de Freitas, Nathalia D M Sperotto, Luis F S M Timmers, Osmar Norberto de Souza, Jaqueline N Picada, Jean Fachini, Juliana Bondan da Silva, Nayara C P de Albuquerque, Maísa D Habenschus, Daniel B Carrão, Bruno A Rocha, Fernando Barbosa Junior, Anderson R M de Oliveira, Alessandra Mascarello, Patrícia Neuenfeldf, Ricardo J Nunes, Héctor R Morbidoni, Maria M Campos, Luiz A Basso, Valnês S Rodrigues-Junior
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6095594?pdf=render

Internet

http://europepmc.org/articles/PMC6095594?pdf=render

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