Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

Metformin has been proposed to operate as an agonist of SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that mimics most of the metabolic responses to calorie restriction. Herein, we present an in silico analysis focusing on the molecular docking and dynamic simulation of the...

Full description

Bibliographic Details
Main Authors: Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Javier A. Menendez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Endocrinology
Subjects:
metformin
SIRT1
aging
NAD+
NAD loss
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00657/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00657/full

Similar Items