A Simplified Liquid Chromatography-Mass Spectrometry Assay for Artesunate and Dihydroartemisinin, Its Metabolite, in Human Plasma

A Simplified Liquid Chromatography-Mass Spectrometry Assay for Artesunate and Dihydroartemisinin, Its Metabolite, in Human Plasma

Artesunate (AS) is a potent antimalarial that is used worldwide for the treatment of malaria. A simple method with a total run time of 12 min was developed and validated for the quantification of AS and dihydroartemisinin (DHA), its active metabolite, in human (heparinized) plasma based on one-step...

Full description

Bibliographic Details
Main Authors: Victor Meléndez, Peter J. Weina, Mark M. Fukuda, Srisombat Wannaying, Robert S. Miller, David Saunders, Apassorn Lim, Nitima Chanarat, Roongnapa Apinan, Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Raveewan Siripokasupkul
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
artesunate
dihydroartemisinin
human plasma
method validation
LC-MS
Online Access:http://www.mdpi.com/1420-3049/15/12/8747/

Internet

http://www.mdpi.com/1420-3049/15/12/8747/

Similar Items