Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms.

Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms.

Cancer stem cells (CSCs) possess high tumor-initiating capacity and have been reported to be resistant to therapeutics. Vice versa, therapy-resistant cancer cells seem to manifest CSC phenotypes and properties. It has been generally assumed that drug-resistant cancer cells may all be CSCs although t...

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Bibliographic Details
Main Authors: Hong Yan, Xin Chen, Qiuping Zhang, Jichao Qin, Hangwen Li, Can Liu, Tammy Calhoun-Davis, Luis Della Coletta, Jim Klostergaard, Izabela Fokt, Stanislaw Skora, Waldemar Priebe, Yongyi Bi, Dean G Tang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3174165?pdf=render

Internet

http://europepmc.org/articles/PMC3174165?pdf=render

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