Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms.
Cancer stem cells (CSCs) possess high tumor-initiating capacity and have been reported to be resistant to therapeutics. Vice versa, therapy-resistant cancer cells seem to manifest CSC phenotypes and properties. It has been generally assumed that drug-resistant cancer cells may all be CSCs although t...
Main Authors: | Hong Yan, Xin Chen, Qiuping Zhang, Jichao Qin, Hangwen Li, Can Liu, Tammy Calhoun-Davis, Luis Della Coletta, Jim Klostergaard, Izabela Fokt, Stanislaw Skora, Waldemar Priebe, Yongyi Bi, Dean G Tang |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3174165?pdf=render |
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