The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis. The RXR pathway plays a critical role in testicular lipid trafficking, and RXRβ-...

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Bibliographic Details
Main Authors: David M. Selva, Veronica Hirsch-Reinshagen, Braydon Burgess, Steven Zhou, Jeniffer Chan, Sean McIsaac, Michael R. Hayden, Geoffrey L. Hammond, A. Wayne Vogl, Cheryl L. Wellington
Format: Article
Language:English
Published: Elsevier 2004-06-01
Series:Journal of Lipid Research
Subjects:
cholesterol efflux
liver X receptor
testes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520318010

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http://www.sciencedirect.com/science/article/pii/S0022227520318010

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