Alternative splicing at a NAGNAG acceptor site as a novel phenotype modifier.
Approximately 30% of alleles causing genetic disorders generate premature termination codons (PTCs), which are usually associated with severe phenotypes. However, bypassing the deleterious stop codon can lead to a mild disease outcome. Splicing at NAGNAG tandem splice sites has been reported to resu...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-10-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2951375?pdf=render |