Complement inhibition attenuates acute kidney injury after ischemia-reperfusion and limits progression to renal fibrosis in mice.

Complement inhibition attenuates acute kidney injury after ischemia-reperfusion and limits progression to renal fibrosis in mice.

The complement system is an essential component of innate immunity and plays a major role in the pathogenesis of ischemia-reperfusion injury (IRI). In this study, we investigated the impact of human C1-inhibitor (C1INH) on the early inflammatory response to IRI and the subsequent progression to fibr...

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Bibliographic Details
Main Authors: Juan S Danobeitia, Martynas Ziemelis, Xiaobo Ma, Laura J Zitur, Tiffany Zens, Peter J Chlebeck, Edwin S Van Amersfoort, Luis A Fernandez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5568291?pdf=render

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http://europepmc.org/articles/PMC5568291?pdf=render

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