Quantile-dependent expressivity of plasma adiponectin concentrations may explain its sex-specific heritability, gene-environment interactions, and genotype-specific response to postprandial lipemia
Background “Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. adiponectin) is high or low relative to its distribution. We have previously shown that the heritability (h2) of adiposity, lipoproteins, postprandial lipemia, pulmo...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2020-10-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/10099.pdf |