In vivo and in vitro Approaches Reveal Novel Insight Into the Ability of Epicardium-Derived Cells to Create Their Own Extracellular Environment

In vivo and in vitro Approaches Reveal Novel Insight Into the Ability of Epicardium-Derived Cells to Create Their Own Extracellular Environment

Human epicardium-derived cells (hEPDCs) transplanted in the NOD-SCID mouse heart after myocardial infarction (MI) are known to improve cardiac function, most likely orchestrated by paracrine mechanisms that limit adverse remodeling. It is not yet known, however, if hEPDCs contribute to preservation...

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Bibliographic Details
Main Authors: Noortje A. M. Bax, Sjoerd N. Duim, Boudewijn P. T. Kruithof, Anke M. Smits, Carlijn V. C. Bouten, Marie José Goumans
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
epicardium-derived cells
extracellular matrix (ECM)
mechanosensitivity
cardiac fibrosis
cardiac remodeling
cardiac repair
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00081/full

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https://www.frontiersin.org/article/10.3389/fcvm.2019.00081/full

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