KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.

KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.

HLA-C is an important ligand for killer immunoglobulin like receptors (KIR) that regulate natural killer (NK) cell function. Based on KIR specificity HLA-C molecules are allocated into two groups, HLA-C1 or HLA-C2; HLA-C2 is more inhibiting to NK cell function than HLA-C1. We studied the clinical im...

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Bibliographic Details
Main Authors: Raj Hanvesakul, Chandrashekhar Kubal, Jason Moore, Desley Neil, Mark Cook, Simon Ball, David Briggs, Paul Moss, Paul Cockwell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3166139?pdf=render

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http://europepmc.org/articles/PMC3166139?pdf=render

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