γδ T cell-mediated antibody-dependent cellular cytotoxicity with CD19 antibodies assessed by an impedance-based label-free real-time cytotoxicity assay

γδ T cell-mediated antibody-dependent cellular cytotoxicity with CD19 antibodies assessed by an impedance-based label-free real-time cytotoxicity assay

γδ T cells are not MHC restricted, elicit cytotoxicity against various malignancies, are present in early post-transplant phases in novel stem cell transplantation (SCT) strategies and have been shown to mediate antibody-dependent cellular cytotoxicity (ADCC) with monoclonal antibodies (mAbs). These...

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Bibliographic Details
Main Authors: Ursula Jördis Eva Seidel, Fabian eVogt, Ludger eGrosse-Hovest, Gundram eJung, Rupert eHandgretinger, Peter eLang
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Immunology
Subjects:
ADCC
therapeutic antibodies
Tumor immunotherapy
γδ T cell expansion
xCELLigence system
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00618/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00618/full

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