Soluble Toll-Like Receptor 4 Impairs the Interaction of Shiga Toxin 2a with Human Serum Amyloid P Component

Soluble Toll-Like Receptor 4 Impairs the Interaction of Shiga Toxin 2a with Human Serum Amyloid P Component

Shiga toxin 2a (Stx2a) is the main virulence factor produced by pathogenic Escherichia coli strains (Stx-producing E. coli, STEC) responsible for hemorrhagic colitis and the life-threatening sequela hemolytic uremic syndrome in children. The toxin released in the intestine by STEC targets the globot...

Full description

Bibliographic Details
Main Authors: Maurizio Brigotti, Valentina Arfilli, Domenica Carnicelli, Francesca Ricci, Pier Luigi Tazzari, Gianluigi Ardissino, Gaia Scavia, Stefano Morabito, Xiaohua He
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Toxins
Subjects:
hemolytic uremic syndrome
HuSAP
Shiga toxins
Toll-like receptor 4
decoy receptors
Online Access:http://www.mdpi.com/2072-6651/10/9/379

Internet

http://www.mdpi.com/2072-6651/10/9/379

Similar Items