Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in silico modeling and experimental validation

Abstract Background Ex vivo disc organ culture systems have become a valuable tool for the development and pre‐clinical testing of potential intervertebral disc (IVD) regeneration strategies. Bovine caudal discs have been widely selected due to their large availability and comparability to human IVD...

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Bibliographic Details
Main Authors: Emily E. McDonnell, Conor T. Buckley
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:JOR Spine
Subjects:
pH
Online Access:https://doi.org/10.1002/jsp2.1141