Remyelination-Promoting DNA Aptamer Conjugate Myaptavin-3064 Binds to Adult Oligodendrocytes In Vitro

Remyelination-Promoting DNA Aptamer Conjugate Myaptavin-3064 Binds to Adult Oligodendrocytes In Vitro

We previously applied Systematic Evolution of Ligands by EXponential enrichment (SELEX) technology to identify myelin-specific DNA aptamers, using crude mouse central nervous system myelin as bait. This selection identified a 40-nucleotide aptamer (LJM-3064). Multiple biotinylated LJM-3064 molecules...

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Bibliographic Details
Main Authors: Mahboubeh Fereidan-Esfahani, Wei Ying Yue, Brandon Wilbanks, Aaron J. Johnson, Arthur E. Warrington, Charles L. Howe, Moses Rodriguez, Louis J. Maher
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
multiple sclerosis
DNA aptamer
human oligodendroglial cell line
oligodendrocytes
oligodendrocyte progenitor cells (OPCs)
Online Access:https://www.mdpi.com/1424-8247/13/11/403

Internet

https://www.mdpi.com/1424-8247/13/11/403

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