Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples

Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples

Abstract Background Because driver mutations provide selective advantage to the mutant clone, they tend to occur at a higher frequency in tumor samples compared to selectively neutral (passenger) mutations. However, mutation frequency alone is insufficient to identify cancer genes because mutability...

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Bibliographic Details
Main Authors: Ivan P. Gorlov, Claudio W. Pikielny, Hildreth R. Frost, Stephanie C. Her, Michael D. Cole, Samuel D. Strohbehn, David Wallace-Bradley, Marek Kimmel, Olga Y. Gorlova, Christopher I. Amos
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Bioinformatics
Subjects:
Catalog of somatic mutations in Cancer
COSMIC
Somatic mutations
Missense
Nonsense
Frameshift mutations
Online Access:http://link.springer.com/article/10.1186/s12859-018-2455-0

Internet

http://link.springer.com/article/10.1186/s12859-018-2455-0

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