Sequence-Based Mapping and Genome Editing Reveal Mutations in Stickleback Hps5 Cause Oculocutaneous Albinism and the casper Phenotype

Sequence-Based Mapping and Genome Editing Reveal Mutations in Stickleback Hps5 Cause Oculocutaneous Albinism and the casper Phenotype

Here, we present and characterize the spontaneous X-linked recessive mutation casper, which causes oculocutaneous albinism in threespine sticklebacks (Gasterosteus aculeatus). In humans, Hermansky-Pudlak syndrome results in pigmentation defects due to disrupted formation of the melanin-containing ly...

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Bibliographic Details
Main Authors: James C. Hart, Craig T. Miller
Format: Article
Language:English
Published: Oxford University Press 2017-09-01
Series:G3: Genes, Genomes, Genetics
Subjects:
genome editing
stickleback
pigmentation
albinism
Hermansky-Pudlak syndrome
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.1125

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.1125

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