Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of filopodia and lamellipodia. Consistent with thi...

Full description

Bibliographic Details
Main Authors: Xuchen Hu, Thomas A Weston, Cuiwen He, Rachel S Jung, Patrick J Heizer, Brian D Young, Yiping Tu, Peter Tontonoz, James A Wohlschlegel, Haibo Jiang, Stephen G Young, Loren G Fong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
accessible cholesterol
NanoSIMS
focal adhesions
cholesterol efflux
Online Access:https://elifesciences.org/articles/50231

Internet

https://elifesciences.org/articles/50231

Similar Items