A novel TRPM8 agonist relieves dry eye discomfort

A novel TRPM8 agonist relieves dry eye discomfort

Abstract Background Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively...

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Bibliographic Details
Main Authors: Jee Myung Yang, Fengxian Li, Qin Liu, Marco Rüedi, Edward Tak Wei, Michael Lentsman, Hyo Seok Lee, Won Choi, Seong Jin Kim, Kyung Chul Yoon
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Ophthalmology
Subjects:
Dry eye
Eyelid
Ocular discomfort
TRPM8
Online Access:http://link.springer.com/article/10.1186/s12886-017-0495-2

Internet

http://link.springer.com/article/10.1186/s12886-017-0495-2

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