CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade

CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade

CTLA-4 is essential for immune tolerance. Heterozygous CTLA4 mutations cause immune dysregulation evident in defective regulatory T cells with low levels of CTLA-4 expression. Biallelic mutations in LRBA also result in immune dysregulation with low levels of CTLA-4 and clinical presentation indistin...

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Bibliographic Details
Main Authors: Josselyn E. Garcia-Perez, Ryan M. Baxter, Daniel S. Kong, Richard Tobin, Martin McCarter, John M. Routes, James Verbsky, Michael B. Jordan, Cullen M. Dutmer, Elena W. Y. Hsieh
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
CTLA4
LRBA
mRNA
ipilimumab
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00998/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00998/full

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