Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling

Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling

Summary: Nuclear-erythroid-2-related factor 2 (Nrf2) is involved in the pathogenesis of different liver diseases. Herein, we first demonstrated that Nrf2 expression was diminished in nonalcoholic steatohepatitis (NASH) liver macrophages. In myeloid Nrf2-deficiency mice, aggravated liver steatosis an...

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Bibliographic Details
Main Authors: Peng Wang, Ming Ni, Yizhu Tian, Hao Wang, Jiannan Qiu, Wenhua You, Song Wei, Yong Shi, Jinren Zhou, Feng Cheng, Jianhua Rao, Ling Lu
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:iScience
Subjects:
Immunology
Physiology
Endocrine System Physiology
Human Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221003953

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http://www.sciencedirect.com/science/article/pii/S2589004221003953

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