Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression

Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression

Abstract Background Deep sequencing of transposon mutant libraries (or TnSeq) is a powerful method for probing essentiality of genomic loci under different environmental conditions. Various analytical methods have been described for identifying conditionally essential genes whose tolerance for inser...

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Bibliographic Details
Main Authors: Siddharth Subramaniyam, Michael A. DeJesus, Anisha Zaveri, Clare M. Smith, Richard E. Baker, Sabine Ehrt, Dirk Schnappinger, Christopher M. Sassetti, Thomas R. Ioerger
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Bioinformatics
Subjects:
TnSeq
Transposon insertion library
Essentiality
Zero-inflated negative binomial distribution
Mycobacterium tuberculosis
Online Access:http://link.springer.com/article/10.1186/s12859-019-3156-z

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http://link.springer.com/article/10.1186/s12859-019-3156-z

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