Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways[S]

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways[S]

Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). However, one report suggested that SFA-induced TLR activation in cell culture systems is due to contaminants in BSA used for solubilizing fatty acids. This rep...

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Bibliographic Details
Main Authors: Shurong Huang, Jennifer M. Rutkowsky, Ryan G. Snodgrass, Kikumi D. Ono-Moore, Dina A. Schneider, John W. Newman, Sean H. Adams, Daniel H. Hwang
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Journal of Lipid Research
Subjects:
docosahexaenoic acid
Toll-like receptors
reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418437

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http://www.sciencedirect.com/science/article/pii/S0022227520418437

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