Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone.

Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone.

Mechanosensory hair cell death is a leading cause of hearing and balance disorders in the human population. Hair cells are remarkably sensitive to environmental insults such as excessive noise and exposure to some otherwise therapeutic drugs. However, individual responses to damaging agents can vary...

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Bibliographic Details
Main Authors: Dale W Hailey, Brock Roberts, Kelly N Owens, Andrew K Stewart, Tor Linbo, Remy Pujol, Seth L Alper, Edwin W Rubel, David W Raible
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3469417?pdf=render

Internet

http://europepmc.org/articles/PMC3469417?pdf=render

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