Inhibition of mitochondria NADH–Ubiquinone oxidoreductase (complex I) sensitizes the radioresistant glioma U87MG cells to radiation

Inhibition of mitochondria NADH–Ubiquinone oxidoreductase (complex I) sensitizes the radioresistant glioma U87MG cells to radiation

Radiation is a current standard treatment of glioma. The fractionated radiotherapy with low dose of radiation over weeks has been employed in glioma patients, while radiotherapy can only offer palliation due to the radioresistance. We cumulatively radiated a glioblastoma cell line, U87MG, and screen...

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Bibliographic Details
Main Authors: Xingjie Gao, Yanqin Yang, Jia Wang, Lu Zhang, Caifeng Sun, Ying Wang, Jingkai Zhang, Haoyu Dong, Han Zhang, Chuanzhou Gao, Bin Zhang, Bin Feng, Weifeng Mao
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Glioma
Mitochondria metabolism
Complex I
Radioresistance
Rotenone
Metformin
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220306533

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http://www.sciencedirect.com/science/article/pii/S0753332220306533

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