Pathway thermodynamics highlights kinetic obstacles in central metabolism.

In metabolism research, thermodynamics is usually used to determine the directionality of a reaction or the feasibility of a pathway. However, the relationship between thermodynamic potentials and fluxes is not limited to questions of directionality: thermodynamics also affects the kinetics of react...

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Bibliographic Details
Main Authors: Elad Noor, Arren Bar-Even, Avi Flamholz, Ed Reznik, Wolfram Liebermeister, Ron Milo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586134/?tool=EBI