Striatal Cholinergic Interneurons Control Motor Behavior and Basal Ganglia Function in Experimental Parkinsonism

Striatal Cholinergic Interneurons Control Motor Behavior and Basal Ganglia Function in Experimental Parkinsonism

Despite evidence showing that anticholinergic drugs are of clinical relevance in Parkinson’s disease (PD), the causal role of striatal cholinergic interneurons (CINs) in PD pathophysiology remains elusive. Here, we show that optogenetic inhibition of CINs alleviates motor deficits in PD mouse models...

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Bibliographic Details
Main Authors: Nicolas Maurice, Martine Liberge, Florence Jaouen, Samira Ztaou, Marwa Hanini, Jeremy Camon, Karl Deisseroth, Marianne Amalric, Lydia Kerkerian-Le Goff, Corinne Beurrier
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715010451

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http://www.sciencedirect.com/science/article/pii/S2211124715010451

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