Vascular Targeting in Pancreatic Cancer: The Novel Tubulin-Binding Agent ZD6126 Reveals Antitumor Activity in Primary and Metastatic Tumor Models

Vascular Targeting in Pancreatic Cancer: The Novel Tubulin-Binding Agent ZD6126 Reveals Antitumor Activity in Primary and Metastatic Tumor Models

ZD6126 is a novel vascular-targeting agent that acts by disrupting the tubulin cytoskeleton of an immature tumor endothelium, leading to an occlusion of tumor blood vessels and a subsequent tumor necrosis. We wanted to evaluate ZD6126 in primary and metastatic tumor models of human pancreatic cance...

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Bibliographic Details
Main Authors: Axel Kleespies, Gudrun Köhl, Michael Friedrich, Anderson J. Ryan, Alan Barge, Karl-Walter Jauch, Christiane J. Bruns
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
vascular targeting
pancreatic cancer
cytoskeleton
orthotopic tumor model
dorsal skinfold chamber
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605801198

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http://www.sciencedirect.com/science/article/pii/S1476558605801198

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