MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma

MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma

Abstract Background MYCN gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the MYCN gene as early as possible in neuroblastoma (NB); however, for patients with bone marrow (BM) metastasis who need chemotherapy before surgery, timely d...

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Bibliographic Details
Main Authors: Zhi-Xia Yue, Cheng Huang, Chao Gao, Tian-Yu Xing, Shu-Guang Liu, Xing-Jun Li, Qian Zhao, Xi-Si Wang, Wen Zhao, Mei Jin, Xiao-Li Ma
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Cancer Cell International
Subjects:
Neuroblastoma
MYCN amplification
Fluorescence in situ hybridization
Bone marrow metastasis
Online Access:http://link.springer.com/article/10.1186/s12935-017-0412-z

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http://link.springer.com/article/10.1186/s12935-017-0412-z

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