Evaluation of Alum-Naltrexone Adjuvant Activity, on Efficacy of Anti-Leishmania Immunization with Autoclaved Leishmania major (MRHO/IR/75/ER) Antigens in BALB/C Mice

Evaluation of Alum-Naltrexone Adjuvant Activity, on Efficacy of Anti-Leishmania Immunization with Autoclaved Leishmania major (MRHO/IR/75/ER) Antigens in BALB/C Mice

Background: Naltrexone, an opioid receptor antagonist shifts the immune response toward a Th1 profile. In the current study, we evaluated the efficacy of the mixture of NTX and alum, as a new adjuvant, to enhance immune response and induce protection against Leishmania major in a mouse model. Meth...

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Bibliographic Details
Main Authors: Habib Mohammadzadeh Hajipirloo, Arezoo Bozorgomd, Shahram Shahabi, Khosrow Hazrati Tappeh, Seyed Ahmad Karamati
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2014-09-01
Series:Iranian Journal of Parasitology
Subjects:
Adjuvant
Alum
Antigen
BALB/c
Leishmania major
Naltrexone
Online Access:https://ijpa.tums.ac.ir/index.php/ijpa/article/view/397

Internet

https://ijpa.tums.ac.ir/index.php/ijpa/article/view/397

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