Isolation and characterization of three new anti-proliferative Sesquiterpenes from Polygonum barbatum and their mechanism via apoptotic pathway

Isolation and characterization of three new anti-proliferative Sesquiterpenes from Polygonum barbatum and their mechanism via apoptotic pathway

Abstract Background The emergence of chemoresistant cancers and toxicity related to existing chemotherapeutic agents, demand the search for new pharmacophore with enhanced anti-cancer activity and least toxicity. For this purpose, three new sesquiterpenes were isolated from ethyl acetate fraction of...

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Bibliographic Details
Main Authors: Umar Farooq, Sadia Naz, Binte Zehra, Ajmal Khan, Syed Abid Ali, Ayaz Ahmed, Rizwana Sarwar, Syed Majid Bukhari, Abdur Rauf, Izhar Ahmad, Yahia Nasser Mabkhot
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Cancer
Subjects:
Polygonum Barbatum
Sesquiterpenes
Non-small cell lung carcinoma
Angiogenesis
VEGF
Cox-2
Online Access:http://link.springer.com/article/10.1186/s12885-017-3667-9

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http://link.springer.com/article/10.1186/s12885-017-3667-9

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