Evaluation of losmapimod in patients with chronic obstructive pulmonary disease (COPD) with systemic inflammation stratified using fibrinogen (‘EVOLUTION’): Rationale and protocol

Evaluation of losmapimod in patients with chronic obstructive pulmonary disease (COPD) with systemic inflammation stratified using fibrinogen (‘EVOLUTION’): Rationale and protocol

Introduction: p38 mitogen-activated protein kinases (MAPK) are key signalling molecules in cellular responses to external stresses, regulate pro-inflammatory cytokine expression and are implicated in the inflammatory pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) and atherosclerosis. T...

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Bibliographic Details
Main Authors: M. Fisk, D. Mohan, J. Cheriyan, L. Yang, J. Fuld, C.M. McEniery, R. Tal-Singer, M.I. Polkey, I.B. Wilkinson
Format: Article
Language:English
Published: Atlantis Press 2013-11-01
Series:Artery Research
Subjects:
COPD
Losmapimod
p38 MAPK inhibitor
Fibrinogen
Inflammation
18F-FDG PET/CT
Online Access:https://www.atlantis-press.com/article/125925225/view

Internet

https://www.atlantis-press.com/article/125925225/view

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