Propofol enhances BCR-ABL TKIs’ inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression

Propofol enhances BCR-ABL TKIs’ inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression

Abstract Background The anti-cancer activities of intravenous anesthetic drug propofol have been demonstrated in various types of cancers but not in chronic myeloid leukemia (CML). Methods We systematically examined the effect of propofol and its combination with BCR-ABL tyrosine kinase inhibitors (...

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Bibliographic Details
Main Authors: Zhimin Tan, Aixia Peng, Jingwen Xu, Mingwen Ouyang
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Anesthesiology
Subjects:
Leukemia
Propofol
Akt/mTOR
Drug repurposing
Online Access:http://link.springer.com/article/10.1186/s12871-017-0423-2

Internet

http://link.springer.com/article/10.1186/s12871-017-0423-2

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