CAR-T design: Elements and their synergistic function

CAR-T design: Elements and their synergistic function

Chimeric antigen receptor (CAR) T cells use re-engineered cell surface receptors to specifically bind to and lyse oncogenic cells. Two clinically approved CAR-T–cell therapies have significant clinical efficacy in treating CD19-positive B cell cancers. With widespread interest to deploy this immunot...

Full description

Bibliographic Details
Main Authors: Jayapriya Jayaraman, Michael P. Mellody, Andrew J. Hou, Ruchi P. Desai, Audrey W. Fung, An Huynh Thuy Pham, Yvonne Y. Chen, Weian Zhao
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:EBioMedicine
Subjects:
Chimeric antigen receptor
CAR-T
Immunotherapy
Cancer
Cell engineering
Synthetic biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303078

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420303078

Similar Items