Plasmacytoid dendritic cells respond directly to apoptotic cells by secreting immune regulatory IL-10 or IFNα

Plasmacytoid dendritic cells respond directly to apoptotic cells by secreting immune regulatory IL-10 or IFNα

Plasmacytoid dendritic cells (pDCs) play a pivotal role in driving the autoimmune disease systemic lupus erythematosus, via the secretion of IFNα in response to nuclear self-antigens complexed with auto-antibodies. Apoptotic cells, generated at sites of inflammation or secondary lymphoid organs, are...

Full description

Bibliographic Details
Main Authors: Joanne Simpson, Katherine Miles, Marta Trub, Roisin MacMahon, Mohini Gray
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Apoptosis
IL-10
plasmacytoid dendritic cells
TLRs (Toll-like receptors)
apoptotic cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00590/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00590/full

Similar Items