Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

Abstract Background Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK2 plays a pivotal role in tumor initiation and maintenance, which provi...

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Bibliographic Details
Main Authors: Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang, Hua Li
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Benserazide
Colorectal cancer
Drug repurposing
HK2 inhibitor
Structure-based virtual ligand screening
Online Access:http://link.springer.com/article/10.1186/s13046-017-0530-4

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http://link.springer.com/article/10.1186/s13046-017-0530-4

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