LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy

LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy

We describe a novel, potent and selective orexin-2 (OX2)/hypocretin-2 receptor antagonist with in vivo activity in an animal model predictive of antidepressant-like efficacy. N-biphenyl-2-yl-4-fluoro-N-(1H-imidazol-2-ylmethyl)benzenesulfonamide HCl (LSN2424100) binds with high affinity to recombina...

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Bibliographic Details
Main Authors: Thomas Edward Fitch, Mark J Benvenga, Cynthia D Jesudason, Charity eZink, Amy B Vandergriff, Michelle eMenezes, Douglas A Schober, Linda M Rorick-Kehn
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Neuroscience
Subjects:
antidepressant
Mouse
rat
hypocretin
Neuropeptide
orexin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00005/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00005/full

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