Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with immune checkpoint inhibitors

Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with immune checkpoint inhibitors

Background: The gut microbiota has been shown to be an important determinant of the efficacy of immune checkpoint inhibitions (ICI) in cancer. Several lines of evidence suggest that antibiotic (ATB) usage prior to or within the first month of ICI initiation negatively impacts clinical outcomes. Meth...

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Bibliographic Details
Main Authors: Arielle Elkrief, Layal El Raichani, Corentin Richard, Meriem Messaoudene, Wiam Belkaid, Julie Malo, Karl Belanger, Wilson Miller, Rahima Jamal, Nathalie Letarte, Philip Wong, Bertrand Routy
Format: Article
Language:English
Published: Taylor & Francis Group 2019-04-01
Series:OncoImmunology
Subjects:
melanoma
immunotherapy
immune check-point inhibition
antibiotics
gut microbiome
dysbiosis
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1568812

Internet

http://dx.doi.org/10.1080/2162402X.2019.1568812

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