Subcritical Fluid Chromatography at Sub-Ambient Temperatures for the Chiral Resolution of Ketamine Metabolites with Rapid-Onset Antidepressant Effects

Subcritical Fluid Chromatography at Sub-Ambient Temperatures for the Chiral Resolution of Ketamine Metabolites with Rapid-Onset Antidepressant Effects

Chiral metabolites of ketamine exerting rapid-onset yet sustained antidepressant effects may be marketed directly in the future, but require chemo- and enantio-selective chromatographic methods for quality assurance and control. The chromatographic behavior of <i>S</i>-/<i>R</i&...

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Bibliographic Details
Main Authors: Robert K. Hofstetter, Felix Potlitz, Lukas Schulig, Simon Kim, Mahmoud Hasan, Andreas Link
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
supercritical CO<sub>2</sub>
sub-ambient temperature
subcritical fluid chromatography
chiral resolution
immobilized
coated
chiral stationary phase
ketamine
metabolites
depression
Online Access:https://www.mdpi.com/1420-3049/24/10/1927

Internet

https://www.mdpi.com/1420-3049/24/10/1927

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