Suppression of interferon lambda signaling by SOCS-1 results in their excessive production during influenza virus infection.

Suppression of interferon lambda signaling by SOCS-1 results in their excessive production during influenza virus infection.

Innate cytokine response provides the first line of defense against influenza virus infection. However, excessive production of cytokines appears to be critical in the pathogenesis of influenza virus. Interferon lambdas (IFN-λ) have been shown to be overproduced during influenza virus infection, but...

Full description

Bibliographic Details
Main Authors: Haitao Wei, Song Wang, Qinghuang Chen, Yuhai Chen, Xiaojuan Chi, Lianfeng Zhang, Shile Huang, George F Gao, Ji-Long Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3879354?pdf=render

Internet

http://europepmc.org/articles/PMC3879354?pdf=render

Similar Items