Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies

Glioblastoma (GBM) is an aggressive brain malignancy with a dismal prognosis. With emerging evidence to disprove brain-immune privilege, there has been much interest in examining immunotherapy strategies to treat central nervous system (CNS) cancers. Unfortunately, the limited success of clinical st...

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Bibliographic Details
Main Authors: Nivedita M. Ratnam, Heather M. Sonnemann, Stephen C. Frederico, Huanwen Chen, Marsha-Kay N. D. Hutchinson, Tyrone Dowdy, Caitlin M. Reid, Jinkyu Jung, Wei Zhang, Hua Song, Meili Zhang, Dionne Davis, Mioara Larion, Amber J. Giles, Mark R. Gilbert
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
immunotherapy
CNS malignancies
GSK126
immune evasion
epigenetic gene silencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.719091/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.719091/full

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